International Journal
of Pharmaceutical Sciences and Drug Research ISSN: 0975-248X | DOI Prefix: 10.25004 | CODEN (USA): IJPSPP

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Volume No.: 10 (2018) Issue No: 1

International Journal of Pharmaceutical Sciences and Drug Research 2018; 10(1): 1-6 http://dx.doi.org/10.25004/IJPSDR. 2018.100101
Research Article

Formulation and Evaluation of Minoxidil Gel Using Acrylamide/Sodium Acryloyldimethyl taurate copolymer for Alopecia areata

Pawan Kumar1, Shailendra Kumar Singh1*, Deepak Kumar Jindal1, Vandana Handa2,

Jyoti Bilonia3


1Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science & Technology, Hisar-125001, Haryana, India

2School of Pharmacy, Krishna Institute of Engineering and Technology, Ghaziabad-201206, Uttar Pradesh, India

3B. N. College of Pharmacy, Udaipur-313001, Rajasthan, India



*Corresponding author: Dr. Shailendra Kumar Singh

  Address: Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science & Technology, Hisar-125001, Haryana, India

  Tel.: +91-9416473355

  Fax: +91-1662276240

E-mail *: sksingh_gju@rediffmail.com

Relevant conflicts of interest/financial disclosures: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Received: 03 October, 2017; Revised: 08 November, 2017; Accepted: 15 November, 2017; Published: 15 January, 2018


Copyright © 2018 Pawan Kumar et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.


Alopecia areata is a common, chronic inflammatory disease, characterized by patchy hair loss on the scalp, affecting about 2.1% of world population. Presently, minoxidil has been used for treatment of alopecia as topical lotion, but associated with many drawbacks like systemic side effects and low contact time with skin. Therefore, in the present work, minoxidil gel was prepared using a novel copolymer, Sepineo P 600 to overcome these drawbacks. The prepared gel was characterized for pH, drug content, viscosity, spreadability, skin adhesivity, occlusivity, in vitro drug release, ex vivo skin permeation, stability and finally for skin corrosivity. The drug content of the finalized gel was found to be 99.80 ± 0.82%. The formulation showed good spreadability, occlusivity, adhesiveness and viscosity. In vitro release studies showed that the drug release from prepared gel followed matrix release pattern as compared to lotion. Mathematical modelling of the drug release data suggested Higuchi release model. The formulated minoxidil gel was found to be non-corrosive and stable when subjected to accelerate as well as real time stability studies. Overall, the minoxidil gel formulation was suitable for skin application and can be an effective dosage form for the treatment of Alopecia areata.


Keywords: Minoxidil, Skin permeation, Sepineo P 600, Gel.



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