• Raveena Shree R Department of Pharmacology, Karnataka College of Pharmacy, Bangalore-560064, Karnataka, India
  • Deepak Kumar Jha Department of Pharmacology, Karnataka College of Pharmacy, Bangalore-560064, Karnataka, India
  • U. RAJASHEKHAR Department of Pharmacology, Karnataka College of Pharmacy, Bangalore-560064, Karnataka, India
  • Nitin Yadav Department of Pharmacology, Karnataka College of Pharmacy, Bangalore-560064, Karnataka, India



Barleria buxifolia, Aspirin, Anti-Oxidant Enzyme, Pro-Inflammatory Cytokines, Ranitidine


The key assessment of the study was evaluating the gastro-protective properties of Barleria buxifolia root extract (REBB) in ulcerative rats. The roots of Barleria buxifolia have properties like antioxidant, anti-inflammatory, and other health benefits. Induction of gastric ulcers was done with aspirin (150 mg/kg, b.w., p.o) for 3 days and was accompanied by treatment with REBB (200 & 400 mg/kg orally) for 15 days. Ranitidine (20 mg/kg, orally) was received as the standard treatment for 14 days. Ulcer index, percent inhibition of ulceration, lipid peroxidation (LPO), TNF-α levels, and histopathological examination of the gastric mucosa were measured. Aspirin-induced stomach ulcers were seen in 100% of the groups, whereas other animal groups, aside from the control group possessed relatively comparable inductions. Ulcer number, ulcer index (p<0.01), and LPO (p<0.05) shown significant reduction in the 400mg/kg and Ranitidine (20mg/kg) when compared to Aspirin induced control group. Whereas the Ulcer score (p<0.001) and TNF-α (p<0.05) showed significant reduction in Ranitidine treated group but showed objectively improvement but statistically non-significant results in 200mg/kg and 400mg/kg REBB. Hence it was found that Baleria buxifolia root extract effectively mitigates aspirin-induced gastric ulceration in rats, underscoring its potential as a gastro protective agent.


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Research Article

How to Cite

“GASTRO-PROTECTIVE EFFECT OF ROOT EXTRACT OF BARLERIA BUXIFOLIA ON ASPIRIN INDUCED GASTRIC ULCER IN RATS”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 16, no. 2, Mar. 2024, pp. 157-62,