• Nidhi Namdev Faculty of Pharmacy, Medi-Caps University, Indore, Madhya Pradesh, India
  • Mousumi Kar Pillai Faculty of Pharmacy, Medi-Caps University, Indore, Madhya Pradesh, India
  • Sujit Pillai Pillai GRY Institute of Pharmacy, Borawan, Dist. Khargone, Madhya Pradesh, India
  • Ruchita Raghuvanshi GRY Institute of Pharmacy, Borawan, Dist. Khargone, Madhya Pradesh, India
  • Ujjawal Ahirwal GRY Institute of Pharmacy, Borawan, Dist. Khargone, Madhya Pradesh, India
  • R Yadav GRY Institute of Pharmacy, Borawan, Dist. Khargone, Madhya Pradesh, India




Mucoadhesive, Analgesia, Tramadol hydrochloride, Chitosan


Mucoadhesion is one of the most extensively studied methods for the administration of medication for faster onset of action with enhanced bioavailability. Present investigation was concerned with the development and characterization of controlled release muco-adhesive drug delivery system for the drug Tramadol Hydrochloride (TRD) to extend the duration of analgesia for patients suffering from acute to chronic pain. Formulations were made using the solvent casting technique, incorporating natural polymers like Guar Gum, Xanthum Gum and Chitosan in conjunction with HPMC (hydroxy propyl methyl cellulose) to modify the drug release. The compatibility of film components were validated by Fourier Transform Infra- Red (FTIR) spectroscopy and subjected to physico-chemical evaluation parameters and ex-vivo drug diffusion study. Optimized formulation was tested for analgesic efficacy in vivo to determine extent of their suitability in therapeutic use. All the prepared formulations exhibited superior pharmaceutical qualities with respect to drug content, folding endurance, swelling index and mucoadhesion time. In ex-vivo drug diffusion study, all the films displayed a controlled release lasting longer than eight hours. Formulations containing Chitosan in combination with HPMC (F6) showed better controlled drug release over other combinations. The formulation F6 bring out remarkable in vivo analgesic efficacy with 58.10 % analgesia in contrast to the standard (61.16%). It was deduced that Tramadol hydrochloride mucoadhesive films were found to be an effective treatment for moderate to severe pain with a quick onset and a lengthy half-life.


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Bassi P, Kaur G. Polymeric Films as a Promising Carrier for Bioadhesive Drug Delivery: Development, Characterization and Optimization. Saudi Pharmaceutical Journal. 2017; 25(1): 32-43. Available from: DOI: 10.1016/j.jsps.2015.06.003

Reddy YK, Tasleem J. Formulation and Evaluation of Bioadhesive Buccal Drug Delivery of Sumatriptan Succinate Tablets. Asian Journal of Pharmaceutical Research. 2020; 10(2): 105-109. Available from: DOI: 10.5958/2231-5691.2020.00020.9

Patil ND., Gondkar S.B., Saudagar R.B. Formulation and Evaluation of Mucoadhesive Buccal Patch of Saxagliptin Hydrochloride. Research Journal of Pharmaceutical Dosage Forms and Technology.2016; 8(4): 237-247. Available from: DOI : 10.5958/0975-4377.2016.00033.1

Mohapatra PK, Boddu PK, Patel PS, Verma HC, Sahoo S. Development and Evaluation of Trans Buccal Patches based on Natural and Synthetic Polymers Loaded with Rivastigmine using Solvent Casting Technique. Research Journal of Pharmacy and Technology. 2021; 14(10): 5133-5140. Available from: DOI : 10.52711/0974- 360X.2021.00894

Gaur K, Kori ML, Tyagi LK, Singh V, Nema RK, Tripathi P. Licofelone Novel Analgesic and Anti-Inflammatory Agent for Osteoarthritis: An Overview. Journal of Young Pharmacists. 2009; 1:67-71. Available from: DOI:10.4103/0975-1483.51884

Pastorio NFG, Vecchi CF, Said DSR, Bruschi ML . Design of Mucoadhesive Strips for Buccal Fast Release of Tramadol. Pharmaceutics. 2021; 31:13(8): 1-17. Available from: doi: 10.3390/ pharmaceutics13081187

Abdullah Z, Ashraf MU, Barkat K, Badshah SF, Rehman U. Formulation of pH-Responsive Highly Swellable Hydrogel Scaffolds for Controlled Release of Tramadol HCl: Characterization and Biocompatibility Evaluation. Frontiers in Bioengineering and Biotechnology. 2023 May 26; 11:1-15. Available from: DOI: 10.3389/fbioe.2023.1190322

Giannoidis P, Furlong A, Macdonald D. Non-union of the Femoral Diaphysis: the Influence of Reaming and Non-Steroidal Antiinflammatory Drugs (NSAIDs). The Journal of Bone and Joint Surgery.2000;82: 655-8. Available from: DOI: 10.1302/0301- 620x.82b5.9899

Haju SS and Yadav S. Formulation and Evaluation of Cilnidipine Mucoadhesive Buccal Film by Solvent Casting Technique for the Treatment of Hypertension. International Journal of Pharmacy and Pharmaceutical Sciences. 2021; 13(9): 34-43. Available from: DOI:10.22159/ijpps.2021v13i9.42641

Patel A, Shah D., Desai T, Noolvi M. Development and Evaluation of Chitosan and Aloe vera Gel Mucilage interpolymer Complex-based Mucoadhesive Buccal Films of Tramadol hydrochloride. Asian Journal of Pharmaceutics. 2016; 10(1): 43-49. Available from: DOI: https://doi.org/10.22377/ajp.v10i1.550

Aswathy B, Shajan A, Steffy PR, Nisha U, Chippy SP, Elessy A, Dibyalochan M. Formulation and Evaluation of Sitagliptin Buccal Patch. Research Journal of Pharmacy and Technology. 2020; 13(10): 4883-4887. Available from: DOI:10.5958/0974-360X.2020.00859.8

Gupta P, Nautiyal U, Sing R. Formulation and Evaluation of Moxifloxacin Hydrochloride Buccal Film. Research in Pharmacy and Health Sciences. 2023; 9(1): 205-208. Available from: https:// doi.org/10.32464/RPHS.2023.v09i01.01

Muzib YI, Kumari KS. Mucoadhesive Buccal Films of Glibenclamide: Development and Evaluation. international journal pharmaceutical invest igat ion. 2011 Jan; 1(1): 42-47. Available from: doi: 10.4103/2230-973X.76728

Maheswara RD, Madhusudhana CC, Reddy Y. Dastagiri, P. Komali, Rani SS. Formulation and Evaluation of Fast Dissolving Buccal Patches of Tenofovir Disoproxil Fumarate. Research Journal of Pharmacy and Technology. 2021; 14(1): 225-230. Available from: DOI: 10.5958/0974-360X.2021.00039.1

Begum SA, Aryani K. Development and Evaluation of Buccal Mucoadhesive patches of Losartan Potassium. Research Journal of Pharmacy and Technology. 2023; 16(7): 3151-6. Available from: DOI: 10.52711/0974-360X.2023.00518

V Jhansipriya Marabathuni , P. Dinesh, R. Ravikumar, P. Yamini, P. SaiKiran, Sd. P. Hussain, Rao M.M. Prasada. Chitosan Based Sustained Release Mucoadhesive Buccal Patches Containing Amlodipine Besylate (AMB). Asian Journal of Research in Pharmaceutical Sciences. 2017; 7(2): 97-104. Available from: DOI:10.5958/2231-5659.2017.00015.7

Aiqin L , Khan IN , Khan IU , Yousaf AM, Shahzad Y. Gellan Gum based Bilayer Mucoadhesive Films loaded with Moxifloxacin Hydrochloride and Clove Oil for Possible Treatment of Periodontitis. Drug Design, Development and Therapy. 2021;16:15: 3937-52. Available from: DOI: 10.2147/DDDT.S328722

Siddique W, Muhammad Z, Muhammad SR. The Development of Eletriptan Hydrobromide Immediate Release Buccal Films Using Central Composite Rotatable Design: An in-vivo and in-vitro Approach. Polymers (Basel). Sep 2022; 23;14(19): 3981. 1-21. Available from: doi: 10.3390/polym14193981.

Jovanovic M, Tomic N, Cvijic S, Stojanovic D, Ibric S, Uskokovic P. Mucoadhesive Gelatin Buccal Films with Propranolol Hydrochloride: Evaluation of Mechanical, Mucoadhesive, and Biopharmaceutical Properties. Pharmaceutics. 2021; 18;13(2): 1-19. Available from: doi: 10.3390/pharmaceutics13020273

Xiao-Qin L, Zhao-Ming Y, Jian-Bing W, Cai-Rong F, Ai-Wu P, Cong L, Ren-Bing Z. Mucoadhesive buccal films of tramadol for effective pain management. Brazilian Journal of Anesthesiology (English Edition). 2017; 67(3): 231-237. Available from: DOI: 10.1016/j. bjan.2016.10.006

Gobel A, Silva JBD, Cook M, Breit KJ. Development of buccal Film Formulations and Their Mucoadhesive Performance in Biomimetic Models. International Journal of Pharmaceutics. 2021; 610: 1-9. Available from: DOI: 10.1016/j.ijpharm.2021.121233

Meher JG, Tarai M, Yadav NP, Patnaik A, Mishra P, Yadav KS. Development and Characterization of Cellulose Polymethacrylate Mucoadhesive Film for Buccal Delivery of Carvedilol. Carbohydrate Polymers. 2013 July; 96(1): 172-180. Available from: https://doi. org/10.1016/j.carbpol.2013.03.076

Bhatta R, Hossain MS, Banik S, Rahman MMM, Rashid MMO, Akter M. Swelling and Mucoadhesive Behavior with Drug Release Characteristics of Gastoretentive Drug Delivery System Based on a Combination of Natural Gum and Semi-synthetic Polymers. Marmara Pharmaceutical Journal. 2018; 22 (2): 286-298. Available from: DOI:10.12991/mpj.2018.66

Muhammet DA , Ayşe PY, Sevde NB. Novel Benz ydamine Hydrochloride and Chlorhexidine Gluconate Loaded Bioadhesive Films for Local Treatment of Buccal Infections. Journal of Drug Delivery Science and Technology. 2023; 84: 104497. Available from: DOI:10.1016/j.jddst.2023.104497






Research Article

How to Cite

“POLYSACCHARIDE BASED CONTROLLED RELEASE MUCOADHESIVE DRUG DELIVERY SYSTEM FOR PAIN MANAGEMENT”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 16, no. 2, Mar. 2024, pp. 206-12, https://doi.org/10.25004/IJPSDR.2024.160210.