• Yash Radhanpura Department of Pharmacology, School of Pharmacy, RK University, Rajkot – 360020, Gujarat, India
  • Harshil Gadhiya Department of Pharmacology, School of Pharmacy, RK University, Rajkot – 360020, Gujarat, India
  • Pravin Tirgar Department of Pharmacology, School of Pharmacy, RK University, Rajkot – 360020, Gujarat, India



Chiari II malformation (CM-II), Chiari I malformation (CM-I), Transient Tachypnea of the Newborn (TTN)


Chiari II malformation (CM-II) is an innate CNS condition in which the medulla oblongata, pons, fourth ventricle, and cerebellum move lower inside the spinal canal. This abnormality is one of the leading causes of neonatal and infant death. The diagnosis of CM-II in the patient necessitates a thorough understanding of the findings. In this case report, we demonstrate a Chiari malformation II identified by MRI of the brain and spine. This case also highlights the need for neuropsychological evaluation in CM-II in terms of providing guidance for psychoeducation and psychotherapy.


Download data is not yet available.


Stevenson KL. Chiari Type II malformation: past, present, and future. Neurosurgical focus. 2004 Feb 1;16(2):1-7. Available from:

Tubbs RS, Oakes WJ. Treatment and management of the Chiari II malformation: an evidence-based review of the literature. Child’s Nervous System. 2004 Jun;20:375-81. Available from: doi. org/10.1007/s00381-004-0969-4

Hidalgo JA, Tork CA, Varacallo M. Arnold chiari malformation. Available from: PMID: 28613730

Hori A. Tectocerebellar dysraphia with posterior encephalocele (Friede): report of the youngest case. Reappraisal of the condition uniting Cleland-Chiari (Arnold-Chiari) and Dandy-Walker syndromes. Clinical neuropathology. 1994 Jul 1;13(4):216-20. Available from: PMID: 7955668

Nagaraj UD, Bierbrauer KS, Zhang B, Peiro JL, Kline-Fath BM. Hindbrain herniation in Chiari II malformation on fetal and postnatal MRI. American Journal of Neuroradiology. 2017 May 1;38(5): Available from: 10.3174/ajnr.A5116

Beuriat PA, Szathmari A, Rousselle C, Sabatier I, Di Rocco F, Mottolese C. Complete reversibility of the Chiari type II malformation after postnatal repair of myelomeningocele. World neurosurgery. 2017 Dec 1;108:62-8. Available from:

McLone DG, Knepper PA. The cause of Chiari II malformation: a unified theory. Pediatric Neurosurgery. 1989 Mar 5;15(1):1-2. Available from:

Piper RJ, Pike M, Harrington R, Magdum SA. Chiari malformations: principles of diagnosis and management. BMJ. 2019 Apr 8;365. Available from:

Meller C, Aiello H, Otaño L. Sonographic detection of open spina bifida in the first trimester: review of the literature. Child’s Nervous System. 2017 Jul;33:1101-6. Available from: s00381-017-3443-9

Zollner U, Rehn M, Girschick G, Dietl J. Sonographic abnormalities of the fetal CNS in the second trimester screening--clarifications according to the new maternity directives. Zeitschrif t fur Geburtshilfe und Neonatologie. 2012 Feb 13;216(1):1-0. Available from:

Adzick NS. Fetal surgery for myelomeningocele: trials and tribulations. Journal of pediatric surgery. 2012 Feb 1;47(2):273-81. Available from:

Liptak GS, Murphy NA, Council on Children With Disabilities. Providing a primary care medical home for children and youth with cerebral palsy. Pediatrics. 2011 Nov 1;128(5):e1321-9. Available from:

Chakraborty A, Crimmins D, Hayward R, Thompson D. Toward reducing shunt placement rates in patients with myelomeningocele. Journal of Neurosurgery: Pediatrics. 2008 May 1;1(5):361-5. Available from:

Brock III JW, Thomas JC, Baskin LS, Zderic SA, Thom EA, Burrows PK, Lee H, Houtrow AJ, MacPherson C, Adzick NS. Effect of prenatal repair of myelomeningocele on urological outcomes at school age. The Journal of urology. 2019 Oct;202(4):812-8. Available from: doi. org/10.1097/JU.0000000000000334






Case Study

How to Cite

“MANAGING CHIARI II MALFORMATION IN A COMPLEX PEDIATRIC CASE: A REPORT”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 16, no. 2, Mar. 2024, pp. 296-8,